Capturing Totipotent Stem Cells
نویسندگان
چکیده
منابع مشابه
Totipotent Embryonic Stem Cells Arise in Ground-State Culture Conditions
Embryonic stem cells (ESCs) are derived from mammalian embryos during the transition from totipotency, when individual blastomeres can make all lineages, to pluripotency, when they are competent to make only embryonic lineages. ESCs maintained with inhibitors of MEK and GSK3 (2i) are thought to represent an embryonically restricted ground state. However, we observed heterogeneous expression of ...
متن کاملTherapeutic Potential of Totipotent, Pluripotent and Multipotent Stem Cells
The discovery of stem cells opened up a whole new arena of research for scientists. And the realizations of their therapeutic potential, promises sustainable cure for previously untreated diseases. Stem cells may broadly be classified into totipotent, pluripotent and multipotent and each of these classes show enormous therapeutic function. Totipotent stem cells can differentiate into 200 cell t...
متن کاملExpansion in vitro of retrovirally marked totipotent hematopoietic stem cells.
A large number of biologic, technological, and clinical studies await the development of procedures that will allow totipotent hematopoietic stem cells to be expanded in vitro. Previous work has suggested that hematopoiesis can be reconstituted using transplants of cells from long-term marrow cultures. We have used retrovirus mediated gene transfer to demonstrate that marked totipotent hematopo...
متن کاملReceptor-mediated endocytosis of transferrin in developmentally totipotent mouse teratocarcinoma stem cells.
The transferrin-mediated pathway of iron uptake has been characterized in mouse teratocarcinoma stem cells in culture. These cells were chosen for the characterization because of their unique capacity to be converted to normalcy and to undergo complete and orderly differentiation into all tissues after microinjection into early mouse embryos. Therefore, the cells provide the possibility of expe...
متن کاملOntogeny of embryogenic callus in Medicago truncatula: the fate of the pluripotent and totipotent stem cells.
BACKGROUND AND AIMS Understanding the fate and dynamics of cells during callus formation is essential to understanding totipotency and the mechanisms of somatic embryogenesis. Here, the fate of leaf explant cells during the development of embryogenic callus was investigated in the model legume Medicago truncatula. METHODS Callus development was examined from cultured leaf explants of the high...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Stem Cell
سال: 2018
ISSN: 1934-5909
DOI: 10.1016/j.stem.2017.12.011